Which word means to make heavier, worse, or more troublesome?

The word that means to make heavier, worse, or more troublesome is "aggravate." In various contexts, aggravate is commonly used to describe situations where a problem or burden is intensified. For instance, you might say that a person's actions can aggravate a situation by adding stress or difficulty.

This term is particularly useful in discussions about issues or conditions that can escalate; therefore, understanding its meaning is crucial for effective communication. The other terms—anecdote, alchemy, and ambidextrous—do not carry the connotation of increasing severity or trouble and refer to completely different concepts. An anecdote is a brief, interesting story; alchemy refers to a historical practice that aimed to transform materials; and ambidextrous describes the ability to use both hands equally well.